House TV Show Cast: A Comprehensive Guide
The medical drama House M.D. (2004–2012) is one of the most acclaimed TV shows of all time, renowned for its sharp writing, gripping cases, and a stellar cast led by Hugh Laurie. From the titular Dr. Gregory House to the supporting characters, the cast brought life and complexity to the show’s dynamic storytelling.
Whether you’re a long-time fan or new to the show, this guide will introduce you to the main cast, their characters, and some interesting behind-the-scenes trivia.
The Cast of House M.D
House M.D. revolves around Dr. Gregory House, a brilliant but misanthropic diagnostician, and his team of medical professionals at Princeton-Plainsboro Teaching Hospital. Each cast member played an essential role in creating the show’s unique blend of humor, drama, and suspense.
Below, we provide an overview of the main cast, their characters, and their real-life backgrounds.

Main Cast of House M.D.: Roles and Stars
Here’s a breakdown of the primary cast:
Hugh Laurie as Dr. Gregory House
- Role: A genius diagnostician with a troubled past, addiction issues, and a sharp tongue.
- About the Actor: Hugh Laurie’s portrayal earned him two Golden Globe Awards. Before House, Laurie was famous for his comedic roles in Blackadder and A Bit of Fry and Laurie.
- Trivia: Laurie auditioned for the role while filming in a hotel bathroom, a fact that impressed the show’s creator, David Shore.
Lisa Edelstein as Dr. Lisa Cuddy
- Role: The Dean of Medicine and House’s boss, as well as a romantic interest.
- About the Actor: Known for her work in TV shows like The West Wing, Edelstein brought strength and vulnerability to the role of Dr. Cuddy.
Robert Sean Leonard as Dr. James Wilson
- Role: House’s best friend and the head of oncology.
- About the Actor: A Tony Award-winning actor, Leonard’s chemistry with Laurie was a cornerstone of the show.
Omar Epps as Dr. Eric Foreman
- Role: A neurologist who is often at odds with House.
- About the Actor: Epps previously appeared in ER and Love & Basketball.
Jennifer Morrison as Dr. Allison Cameron
- Role: An immunologist with a strong moral compass.
- About the Actor: Morrison later starred in Once Upon a Time.
Jesse Spencer as Dr. Robert Chase
- Role: An intensivist with a complicated past.
- About the Actor: Spencer, an Australian actor, is also known for his role in Chicago Fire.
Olivia Wilde as Dr. Remy “Thirteen” Hadley
- Role: A diagnostician struggling with a personal health crisis.
- About the Actor: Wilde became a fan favorite and went on to direct critically acclaimed films like Booksmart.
Step-by-Step Overview: Evolution of the House M.D. Cast
Season 1–3: The Original Team
- Dr. Cameron, Dr. Chase, and Dr. Foreman form the initial team working under House.
- The trio has distinct dynamics, with ethical clashes often playing a central role in their storylines.
Season 4–5: New Faces Join the Team
- House holds a competitive hiring process, introducing characters like Dr. Thirteen (Olivia Wilde), Dr. Kutner (Kal Penn), and Dr. Taub (Peter Jacobson).
Season 6–8: A Shift in Dynamics
- As the show progresses, the cast undergoes several changes, with some characters departing and new ones, like Dr. Adams (Odette Annable), joining.
Top 5 Memorable Cast Moments in House M.D.
- House’s Infamous Cane-Smashing Scene (Season 1): Hugh Laurie perfectly portrays House’s frustration in this iconic scene.
- Cuddy and House’s Romantic Tension: The chemistry between Laurie and Edelstein shines.
- Thirteen’s Personal Struggles: Wilde’s performance brought depth to a challenging storyline.
- Wilson and House’s Road Trip: A lighthearted yet poignant episode that explores their friendship.
- The Series Finale: A fitting farewell to one of TV’s most beloved casts.
Behind-the-Scenes Trivia About the Cast
- Hugh Laurie’s Accent: Laurie’s flawless American accent led some producers to believe he was American during his audition.
- On-Set Chemistry: Robert Sean Leonard and Hugh Laurie became close friends off-screen, mirroring their characters’ relationship.
- Olivia Wilde’s Breakout Role: Wilde credits House with launching her career in Hollywood.

FAQs About the House M.D. Cast
1. Who played Dr. Gregory House?
Hugh Laurie portrayed Dr. Gregory House, earning widespread critical acclaim.
2. Why did Lisa Edelstein leave House M.D.?
Edelstein left due to contract disputes before the final season.
3. Did any cast members win awards for their roles?
Hugh Laurie won multiple Golden Globes, and the ensemble cast received various nominations.
4. What happened to Kal Penn’s character, Dr. Kutner?
Dr. Kutner’s death shocked fans in Season 5, written to accommodate Penn’s departure to work at the White House.
5. Where can I watch House M.D.?
The show is available on streaming platforms like Amazon Prime, Peacock, and Hulu.
The cast of House M.D. delivered performances that elevated the series to iconic status. House TV Show Cast From Hugh Laurie’s unforgettable portrayal of Dr. House to Olivia Wilde’s compelling performance as Thirteen, each actor left a lasting impression.
Whether you’re revisiting the show or exploring it for the first time, the stellar ensemble ensures a captivating experience.